| Round | Date | Opponents | Venue | Score | Att |
| 3rd Rd Q 1 | 29.07.10 | FC Rabotnicki | A | 0-2 | 23,000 |
| 3rd Rd Q 2 | 05.08.10 | FC Rabotnicki | H | 2-0 | 31,202 |
| P-O 1st L | 19.08.10 | Trabzonspor | H | 1-0 | 40,941 |
| P-O 2nd L | 26.08.10 | Trabzonspor | A | 1-1 | 21,065 |
| Matchday 1 | 16.09.10 | S Bucharest | H | 4-1 | 25,605 |
| Matchday 2 | 30.09.10 | FC Utrecht | A | 0-0 | 23,662 |
| Matchday 3 | 21.10.10 | Napoli | A | 0-0 | 55,489 |
| Matchday 4 | 04.11.10 | Napoli | H | 3-1 | 33,895 |
| Matchday 5 | 02.12.10 | S Bucharest | A | 1-1 | 20,000 |
| Matchday 6 | 15.12.10 | FC Utrecht | H | 0-0 | 37,800 |
| Last 32 1L | 17.02.11 | Sparta Prague | A | 0-0 | 17,564 |
| Last 32 2L L | 24.02.11 | Sparta Prague | H | 1-0 | 34,941 |
| Last 16 1L | 10.03.11 | Sporting Braga | A | 1-0 | 12,991 |
| Last 16 L | 17.03.11 | Sporting Braga | H | 0-0 | 37,494 |