| Date | Opponents | Match Possession % |
| Date: 14.08.2021 Matchday: 1 |
Norwich City Venue: Carrow Road, Norwich |
Norwich City 49.3% Liverpool 50.3% |
| Date: 21.08.2021 Matchday: 2 |
Burnley Venue: Anfield, Liverpool |
Liverpool 66.1% Burnely 33.4% |
| Date: 28.08.2021 Matchday: 3 |
Chelsea Venue: Anfield, Liverpool |
Liverpool 65.7% Chelsea 34.3% |
| Date: 12.09.2021 Matchday: 4 |
Leeds United Venue: Elland Road, Leeds |
Leeds United 44.1% Liverpool 55.9% |
| Date: 18.09.2021 Matchday: 5 |
Crystal Palace Venue: Anfield, Liverpool |
Liverpool 59.9% Crystal Palace 40.1% |
| Date: 26.09.2021 Matchday: 6 |
Brentford Venue: Brentford CS, London |
Brentford 32.7% Liverpool 67.3% |
| Date: 03.10.2021 Matchday: 7 |
Manchester City Venue: Anfield, Liverpool |
Liverpool 48.3% Manchester City 51.7% |
| Date: 16.10.2021 Matchday: 8 |
Watford Venue: Vicarage Road, Watford |
Watford 23.3% Liverpool 76.7% |
| Date: 24.10.2021 Matchday: 9 |
Manchester United Venue: Old Trafford, Manchester |
Manchester United 36.3% Liverpool 67.7% |
| Date: 30.10.2021 Matchday: 10 |
Brighton Venue: Anfield, Liverpool |
Liverpool 58.6% Brighton 41.4% |
| Date: 07.11.2021 Matchday: 11 |
West Ham United Venue: London Stadium, London |
West Ham United 30.9% Liverpool 69.1% |
| Date: 20.11.2021 Matchday: 12 |
Arsenal Venue: Anfield, Liverpool |
Liverpool 62.5% Arsenal 37.5% |
| Date: 27.11.2021 Matchday: 13 |
Southampton Venue: Anfield, Liverpool |
Liverpool 64.4% Arsenal 35.6% |
| Date: 01.12.2021 Matchday: 14 |
Everton Venue: Goodison Park, Liverpool |
Everton 30.9% Liverpool 60.9% |
| Date: 04.12.2021 Matchday: 15 |
Wolves Venue: Molineux, Wolverhampton |
Wolves 33.2% Liverpool 66.8% |
| Date: 11.12.2021 Matchday: 16 |
Aston Villa Venue: Anfield, Liverpool |
Liverpool 62.9% Aston Villa 37.1% |
| Date: 16.12.2021 Matchday: 17 |
Newcastle United Venue: Anfield, Liverpool |
Liverpool 74.3% Newcastle United 25.7% |
| Date: 19.12.2021 Matchday: 18 |
Tottenham Hotspur Venue: Tottenham Hotspur Stadium, London |
Tottenham Hotspur 43.5% Liverpool 56.5% |
| Date: 28.12.2021 Matchday: 19 |
Leicester City Venue: King Power Stadium, Leicester |
Leicester City 36.5% Liverpool 63.5% |
| Date: 02.01.2022 Matchday: 21 |
Chelsea Venue: Stamford Bridge, London |
Chelsea 56.0% Liverpool 44.0% |
| Date: 16.01.2022 Matchday: 22 |
Brentford Venue: Anfield, Liverpool |
Liverpool 68.3% Brentford 31.7% |
| Average | 62.22% |