| Date | Opponents | Match Possession % |
| Date: 14.08.2021 Matchday: 1 |
Norwich City Venue: Carrow Road, Norwich |
Norwich City 49.3% Liverpool 50.3% |
| Date: 21.08.2021 Matchday: 2 |
Burnley Venue: Anfield, Liverpool |
Liverpool 66.1% Burnely 33.4% |
| Date: 28.08.2021 Matchday: 3 |
Chelsea Venue: Anfield, Liverpool |
Liverpool 65.7% Chelsea 34.3% |
| Date: 12.09.2021 Matchday: 4 |
Leeds United Venue: Elland Road, Leeds |
Leeds United 44.1% Liverpool 55.9% |
| Date: 18.09.2021 Matchday: 5 |
Crystal Palace Venue: Anfield, Liverpool |
Liverpool 59.9% Crystal Palace 40.1% |
| Date: 26.09.2021 Matchday: 6 |
Brentford Venue: Brentford CS, London |
Brentford 32.7% Liverpool 67.3% |
| Date: 03.10.2021 Matchday: 7 |
Manchester City Venue: Anfield, Liverpool |
Liverpool 48.3% Manchester City 51.7% |
| Date: 16.10.2021 Matchday: 8 |
Watford Venue: Vicarage Road, Watford |
Watford 23.3% Liverpool 76.7% |
| Date: 24.10.2021 Matchday: 9 |
Manchester United Venue: Old Trafford, Manchester |
Manchester United 36.3% Liverpool 67.7% |
| Date: 30.10.2021 Matchday: 10 |
Brighton Venue: Anfield, Liverpool |
Liverpool 58.6% Brighton 41.4% |
| Date: 07.11.2021 Matchday: 11 |
West Ham United Venue: London Stadium, London |
West Ham United 30.9% Liverpool 69.1% |
| Date: 20.11.2021 Matchday: 12 |
Arsenal Venue: Anfield, Liverpool |
Liverpool 62.5% Arsenal 37.5% |
| Date: 27.11.2021 Matchday: 13 |
Southampton Venue: Anfield, Liverpool |
Liverpool 64.4% Arsenal 35.6% |
| Date: 01.12.2021 Matchday: 14 |
Everton Venue: Goodison Park, Liverpool |
Everton 30.9% Liverpool 60.9% |
| Date: 04.12.2021 Matchday: 15 |
Wolves Venue: Molineux, Wolverhampton |
Wolves 33.2% Liverpool 66.8% |
| Date: 11.12.2021 Matchday: 16 |
Aston Villa Venue: Anfield, Liverpool |
Liverpool 62.9% Aston Villa 37.1% |
| Date: 16.12.2021 Matchday: 17 |
Newcastle United Venue: Anfield, Liverpool |
Liverpool 74.3% Newcastle United 25.7% |
| Date: 19.12.2021 Matchday: 18 |
Tottenham Hotspur Venue: Tottenham Hotspur Stadium, London |
Tottenham Hotspur 43.5% Liverpool 56.5% |
| Date: 23.02.2022 Matchday: 19 |
Leeds United Venue: Anfield, Liverpool |
Liverpool 63.7% Leeds United 36.3% |
| Date: 28.12.2021 Matchday: 20 |
Leicester City Venue: King Power Stadium, Leicester |
Leicester City 36.5% Liverpool 63.5% |
| Date: 02.01.2022 Matchday: 21 |
Chelsea Venue: Stamford Bridge, London |
Chelsea 56.0% Liverpool 44.0% |
| Date: 16.01.2022 Matchday: 22 |
Brentford Venue: Anfield, Liverpool |
Liverpool 68.3% Brentford 31.7% |
| Date: 23.01.2022 Matchday: 23 |
Crystal Palace Venue: Selhurst Palace, London |
Crystal Palace 43.2% Liverpool 56.8% |
| Date: 10.02.2022 Matchday: 24 |
Leicester City Venue: Anfield, Liverpool |
Liverpool 65.2% Leicester City 34.8% |
| Date: 13.02.2022 Matchday: 25 |
Burnley Venue: Turf Moor, Burnely |
Burnley 32.7% Liverpool 67.3% |
| Date: 23.02.2022 Matchday: 26 |
Norwich City Venue: Anfield, Liverpool |
Liverpool 69.7% Norwich City 30.3% |
| Date: 05.03.2022 Matchday: 27 |
West Ham United Venue: Anfield, Liverpool |
Liverpool 68.6% West Ham United 31.4% |
| Date: 12.03.2022 Matchday: 28 |
Brighton Venue: Amex Stadium, Brighton |
Brighton 51.70% West Ham United 48.30% |
| Date: 16.03.2022 Matchday: 29 |
Arsenal Venue: Emirates Stadium, London |
Arsenal 48.70% Liverpool 51.30% |
| Date: 02.04.2022 Matchday: 30 |
Watford Venue: Anfield, Liverpool |
Liverpool 73.20% Watford 26.80% |
| Date: 10.04.2022 Matchday: 31 |
Manchester City Venue: Etihad Stadium, Manchester |
Manchester City 55.00% Liverpool 45.00% |
| Date: 19.04.2022 Matchday: 32 |
Manchester United Venue: Anfield, Liverpool |
Liverpool 71.60% Manchester United 28.40% |
| Date: 24.04.2022 Matchday: 33 |
Everton Venue: Anfield, Liverpool |
Liverpool 82.70% Manchester United 17.30% |
| Date: 30.04.2022 Matchday: 34 |
Newcastle United Venue: St James Park, Newcastle |
Newcastle United 34.50% Liverpool 65.5% |
| Date: 07.05.2022 Matchday: 35 |
Tottenham Hotspur Venue: Anfield, Liverpool |
Liverpool 64.90% Tottenham Hotspur 35.10% |
| Date: 10.05.2022 Matchday: 36 |
Aston Villa Venue: Villa Park, Birmingham |
Aston Villa 39.50% Liverpool 60.50% |
| Date: 17.05.2022 Matchday: 37 |
Southampton Venue: St Marys Stadium, Southampton |
Southampton 29.10% Liverpool 70.90% |
| Date: 22.05.2022 Matchday: 38 |
Wolverhampton Wanderers Venue: Anfield, Liverpool |
Liverpool 63.00% Wolves 37.00% |
| Average | 63.03% |