| Date: | Opponent: | Score: |  |
 |
 |
Total: | Referee: |
| Matchday 1: 14.08.2021 |
Norwich City: Venue: Carrow Road |
3:0 | 1 | 0 | 0 | 1 | Andre Marriner 1. Match in Charge |
| Matchday 4: 12.09.2021 |
Leeds United: Venue: Elland Road |
3:0 | 1 | 0 | 0 | 1 | Craig Pawson 1. Match in Charge |
| Matchday 5: 18.09.2021 |
Crystal Palace: Venue: Anfield |
3:0 | 3 | 0 | 0 | 3 | Andy Madley 1. Match in Charge |
| Matchday 6: 25.09.2021 |
Brentford: Venue: Brentford CS |
3:3 | 1 | 0 | 0 | 1 | Stuart Atwell 1. Match in Charge |
| Matchday 7: 03.10.2021 |
Manchester City: Venue: Anfield |
2:2 | 3 | 0 | 0 | 3 | Paul Tierney 1. Match in Charge |
| Matchday 10: 30.10.2021 |
Brighton: Venue: Anfield |
2:2 | 2 | 0 | 0 | 2 | Mike Dean 2. Match in Charge |
| Matchday 11: 07.11.2021 |
West Ham United: Venue: London Stadium |
2:3 | 1 | 0 | 0 | 1 | Craig Pawson 2. Match in Charge |
| Matchday 12: 20.11.2021 |
Arsenal: Venue: Anfield |
4:0 | 2 | 0 | 0 | 2 | Michael Oliver 1. Match in Charge |
| Matchday 14: 01.12.2021 |
Everton: Venue: Goodison Park |
4:1 | 3 | 0 | 0 | 3 | Paul Tierney 2. Match in Charge |
| Matchday 15: 04.12.2021 |
Wolves: Venue: Molineux |
1:0 | 2 | 0 | 0 | 2 | Chris Kavanagh 1. Match in Charge |
| Matchday 16: 11.12.2021 |
Aston Villa: Venue: Anfield |
1:0 | 1 | 0 | 0 | 1 | Stuart Attwell 2. Match in Charge |
| Matchday 17: 16.12.2021 |
Newcastle United: Venue: Anfield |
3:1 | 1 | 0 | 0 | 1 | Mike Dean 3. Match in Charge |
| Matchday 18: 19.12.2021 |
Tottenham Hotspur: Venue: Tottenham Hotspur Stad |
2:2 | 4 | 0 | 1 | 5 | Paul Tierney 3. Match in Charge |
| Matchday 19: 28.12.2021 |
Leicester City: Venue: King Power Stadium |
0:1 | 1 | 0 | 0 | 1 | Micheal Oliver 2. Match in Charge |
| Matchday 21: 02.01.2022 |
Chelsea: Venue: Stamford Bridge |
2:2 | 2 | 0 | 0 | 2 | Anthony Taylor 3. Match in Charge |
| Matchday 23: 23.01.2022 |
Crystal Palace: Venue: Selhurst Park |
3:1 | 1 | 0 | 0 | 1 | Kevin Friend 1. Match in Charge |
| Matchday 24: 10.02.2022 |
Leicester City: Venue: Anfield |
2:0 | 1 | 0 | 0 | 1 | Chris Kavanah 2. Match in Charge |
| Matchday 25: 13.02.2022 |
Burnley: Venue: Turf Moor |
1:0 | 1 | 0 | 0 | 1 | Martin Atkinson 1. Match in Charge |
| Matchday 27: 05.03.2022 |
West Ham United: Venue: Anfield |
1:0 | 2 | 0 | 0 | 2 | Jonathan Moss 3. Match in Charge |
| Matchday 28: 12.03.2022 |
Brighton: Venue: Amex Stadium |
2:0 | 1 | 0 | 0 | 1 | Mike Dean 5. Match in Charge |
| Matchday 29: 16.03.2022 |
Arsenal: Venue: Emirates Stadium |
2:0 | 1 | 0 | 0 | 1 | Andre Marriner 3. Match in Charge |
| Matchday 30: 02.04.2022 |
Watford: Venue: Anfield |
2:0 | 1 | 0 | 0 | 1 | Stuart Attwell 3. Match in Charge |
| Matchday 31: 10.04.2022 |
Manchester City: Venue: Etihad Stadium |
2:2 | 4 | 0 | 0 | 4 | Anthony Taylor 4. Match in Charge |
| Matchday 32: 19.04.2022 |
Manchester United: Venue: Anfield |
4:0 | 1 | 0 | 0 | 1 | Martin Atkinson 2. Match in Charge |
| Matchday 33: 24.04.2022 |
Everton: Venue: Anfield |
2:0 | 2 | 0 | 0 | 2 | Stuart Attwell 4. Match in Charge |
| Matchday 34: 30.04.2022 |
Newcastle United: Venue: St James Park |
1:0 | 3 | 0 | 0 | 3 | Andre Marriner 4. Match in Charge |
| Matchday 35: 07.05.2022 |
Tottenham Hotspur: Venue: Anfield |
1:1 | 3 | 0 | 0 | 3 | Michael Oliver 4. Match in Charge |
| Matchday 38: 22.05.2022 |
Wolverhampton Wanderers: Venue: Anfield |
3:1 | 1 | 0 | 0 | 1 | Anthony Taylor 5. Match in Charge |