| Date | Home | Score | Away |  |
 |
 |
Total | Referee |
| 15.09.2021 | Liverpool | 3:2 | AC Milan | 1 | 0 | 0 | 1 | Szymon Marciniak |
| 21.09.2021 | Norwich City | 0:3 | Liverpool | 0 | 0 | 0 | 0 | Darren England |
| 28.09.2021 | Porto | 1:5 | Liverpool | 0 | 0 | 0 | 0 | Sergei Karasev |
| 19.10.2021 | Atletico Madrid | 2:3 | Liverpool | 2 | 0 | 0 | 2 | Daniel Siebert |
| 27.10.2021 | Preston | 0:2 | Liverpool | 0 | 0 | 0 | 0 | David Coote |
| 03.11.2021 | Liverpool | 2:0 | Atletico Madrid | 3 | 0 | 0 | 3 | Danny Makkelie |
| 24.11.2021 | Liverpool | 2:0 | Porto | 2 | 0 | 0 | 2 | Felix Zwayer |
| 07.12.2021 | AC Milan | 1:2 | Liverpool | 0 | 0 | 0 | 0 | Danny Makkelie |
| 22.12.2021 | Liverpool | 3:3 (p) | Leicester City | 1 | 0 | 0 | 1 | Andrew Madley |
| 09.01.2022 | Liverpool | 4:1 | Shrewsbury Town | 0 | 0 | 0 | 0 | David Coote |
| 13.01.2022 | Liverpool | 0:0 | Arsenal | 1 | 0 | 0 | 1 | Michael Oliver |
| 20.01.2022 | Arsenal | 2:0 | Liverpool | 3 | 0 | 0 | 3 | Martin Atkinson |
| 06.02.2022 | Liverpool | 3:1 | Cardiff City | 1 | 0 | 0 | 1 | Andrew Madley |
| 16.02.2022 | Inter Milan | 0:2 | Liverpool | 0 | 0 | 0 | 0 | Szymon Marciniak |
| 27.02.2022 | Chelsea | 0:0 (p) | Liverpool | 1 | 0 | 0 | 0 | Stuart Attwell |
| 02.03.2022 | Liverpool | 2:1 | Norwich City | 2 | 0 | 0 | 0 | Martin Atkinson |
| 08.03.2022 | Liverpool | 0:1 | Inter Milan | 3 | 0 | 0 | 0 | Antonio M Lahoz |
| 08.03.2022 | Notts Forest | 0:1 | Liverpool | 1 | 0 | 0 | 1 | Craig Pawson |
| 05.04.2022 | Benfica | 1:3 | Liverpool | 1 | 0 | 0 | 1 | Jesus Gil Manzano |
| 13.04.2022 | Liverpool | 3:3 | Benfica | 0 | 0 | 0 | 0 | Serdar Gözübüyük |
| 16.04.2022 | Manchester City | 2:3 | Liverpool | 3 | 0 | 0 | 3 | Michael Oliver |
| 27.04.2022 | Liverpool | 2:0 | Villarreal | 1 | 0 | 0 | 1 | Szymon Marciniak |
| 03.05.2022 | Villarreal | 2:3 | Liverpool | 1 | 0 | 0 | 1 | Danny Makkelie |
| 14.05.2022 | Chelsea | 0:0 (p) | Liverpool | 0 | 0 | 0 | 0 | Craig Pawson |
| 28.05.2022 | Liverpool | 0:1 | Real Madrid | 1 | 0 | 0 | 0 | Clemet Turpin |