| Date | Opponent | Result/Score |
| Matchday: 3 Date: 28.08.2021 |
Opponent: Chelsea Venue: Anfield |
Score: 1:1 Result: Draw |
| Matchday: 6 Date: 25.09.2021 |
Opponent: Brentford Venue: Brentford C Stadium |
Score: 3:3 Result: Draw |
| Matchday: 11 Date: 07.11.2021 |
Opponent: West Ham United Venue: London Stadium |
Score: 2:3 Result: Lost |
| Matchday: 17 Date: 16.12.2021 |
Opponent: Newcastle United Venue: Anfield |
Score: 3:1 Result: Won |
| Matchday: 18 Date: 19.12.2021 |
Opponent: Tottenham Hotspur Venue: Tottenham Hotspur Stadium |
Score: 2:2 Result: Draw |
| Matchday: 19 Date: 28.12.2021 |
Opponent: Leicester City Venue: Leicester City |
Score: 0:1 Result: Lost |